A killer combination
نویسندگان
چکیده
منابع مشابه
Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?
Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the...
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Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...
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Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 sup...
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The article reporting on the exacerbated atherosclerosis in the double mutant, Lyst, LDL receptor (LDLR) knockout is important in drawing attention to the possible involvement of natural killer (NK) cells in atherogenesis.1 It is appropriate that NK cells come into focus: a recent review on immune mechanisms in atherosclerosis made scant mention of NK cells,2 and they are important cytolytic ce...
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Microglia, the resident immune cells of the brain, are important determinants of CNS inflammation. They play defense in the healthy brain, but microglial activation can also lead to neuronal injury or death. The microglial potassium channel Kv1.3 is involved in microglial proliferation and in the respiratory burst that generates reactive oxygen species such as superoxide; thus Fordyce et al. ex...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2009
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.408